姓名：何钟磊 职称：校聘副教授
主要学习与工作经历：
· 2011年09月-2015年07月：清华大学，生物科学与技术，本科
· 2015年10月-2020年07月：爱尔兰都柏林理工大学，转化医学，理学博士
· 2020年11月-2022年11月：爱尔兰都柏林大学，转化医学，博士后研究员
· 2022年11月-2025年8月：爱尔兰Branca Bunus基因治疗技术有限公司，首席技术官
· 2025年08月-至今：台州学院医学院，校聘副教授
主要研究方向：
1. 基因递送与细胞基因治疗技术开发；
2. 纳米递送系统及聚合物材料优化；
代表性研究成果：
近5年一作/通讯（含共同）
1. He, Z., Liu, K., Scally, L. et al. Cold Atmospheric Plasma Stimulates Clathrin-Dependent Endocytosis to Repair Oxidised Membrane and Enhance Uptake of Nanomaterial in Glioblastoma Multiforme Cells. Sci Rep 10, 6985 (2020).
2. He, Z., Xu, Q., Wang, W. et al. Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword. Journal of Materials Chemistry B, 9(32), 6326-6346 (2021).
3. He, Z., Charleton, C., Curtin, J. F. et al. Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma. European Journal of Medicinal Chemistry, 224, 113736 (2021).
4. Gunes, S.#, He, Z.#, Curtin, James., et al. ‘Cell death induced in Glioblastoma cells by Plasma-Activated-Liquids (PAL) is primarily mediated by membrane lipid peroxidation and not ROS influx’. PLOS ONE, 17, 9, (2022).
5. Li, Y. #, He, Z. #, Wang, W. et al. ‘Hyper-branched poly(β-amino ester)s (HPAEs) structure optimisation for enhanced gene delivery: non-ideal terminations elimination’. Nanomaterials, 12(21), 3892 (2022).
6. Zhang, J. #, He, Z. #, Li, Y., Shen, Y., Wu, G., Power, L., ... & Wang, W. (2023). Enhanced Gene Transfection Efficacy and Safety through Granular Hydrogel Mediated Gene Delivery Process. ACTA BIOMATERIALIA, 2023, 15, 1518.
7. Li, Y. #, He, Z. #, Sigen, A., Wang, X., Li, Z., Johnson, M., Foley, R., Lara-Sáez, I., Lyu, J.*, Wang, W.*, ‘Artificial Intelligence (AI)-aided Structure Optimization for Enhanced Gene Delivery: The Effect of Polymer Component Distribution (PCD)’. ACS APPLIED MATERIALS & INTERFACES, 2023.
8. Li, Y. #, He, Z. #, Wang, X., Li, Z., Wang, W.*, et al. ‘Branch Unit Distribution Matters for Gene Delivery’. ACS MACRO LETTERS, 2023.
9. Wang, X., He, Z.*，et al. "Adeno‐associated virus vectors for gene therapy—focusing on melanoma." Interdisciplinary Medicine 2.4 (2024): e20240031.
10. Huang, R., Wang, W.*, He, Z.* et al, ‘Neurotransmitter-endcapped poly(β-amino estate) for enhanced DNA delivery to the brain through intravenous injection’, International Journal of Biological Macromolecules, Volume 322, Part 1, 2025, 146660.
联系方式：
地址：浙江省台州市椒江区市府大道1139号医学院
Email：zhongleihe@tzc.edu.cn
