全面主持学院行政工作。主管学院发展规划、学科建设、教学基层组织建设、人才引进、财务管理等。联系附属医院及临床医学院。
曹轩,教授、博导,台州学院医学院院长
主要学习与工作经历:
1996.9-2000.6: 湖南师范大学生命科学学院,本科,学士
2003.9-2008.6: 武汉大学生命科学学院,硕博连读,博士
2008.10-2013.10: 加拿大Western University医学院,博士后
2013.10-2015.3: 加拿大Western University医学院,副研究员
2015.3-2020.8: 华中科技大学同济基础医学院,教授、博导,支部书记
2020.8-2023.2: 华中科技大学同济基础医学院,教授、博导,副院长
2023.2-至今: 台州学院医学院,教授、硕导、学科领军人才,院长
主要科研成果、荣誉与学术任职:
以第一或通讯作者Nature Communications,PNAS,Theranostics,Biosensors & bioelectronics, JECCR, Clinical and translational medicine, Cell death & disease,Analytica chimica acta,FASEB J等国际知名刊物发表十余篇研究论文,获中国发明专利4项、PCT国际发明专利1项。主持国家自然科学基金面上项目4项(2015、2017、2019、2024)、湖北省杰出青年基金1项、武汉科技晨光计划1项。2016年入选湖北省委组织部百人计划,2016年获湖北省科技进步奖三等奖,2019年入选华中科技大学华中卓越学者,2022年获湖北省教学成果奖二等奖。浙江省生物医学学会理事。《医药导报》编委。台州市博士联谊会常务理事。
主要研究方向:
1.癌症、糖尿病、心血管疾病等慢性疾病的发生发展分子机制研究与新型靶向药物研发。
2.中药活性成分抗癌、糖尿病、心血管疾病等慢性疾病的作用分子机制研究。
3.环境分子医学与环境分子毒理学。
主要研究论文(第一作者或通讯作者):
2024年度:
Yazhou Sang#, Yue Hu#, Yueyue Zhang, Luyi Chen, Yutian Lu, Lin Gao, Yunyun Lu, Xuan Cao曹轩*, Yaqiong Zhang , Guofu Chen“Network pharmacology, molecular docking and biological verification to explore the potential anti-prostate cancer mechanisms of Tripterygium wilfordii Hook. F.” Journal of Ethnopharmacology 2025, 338(Pt 2):119071. Epub 2024 Nov 9(IF:4.8,中科院小类一区top期刊)
Ya Zhu, Lan Li, Shaokui Yi, Rui Hu, Jianjun Wu, Jinqian Xu, Junguang Xu, Qinnan Zhu, Shijia Cen, Yuxuan Yuan, Da Sun, Waqas Ahmad, Huilan Zhang, Xuan Cao曹轩*, Jingjuan Ju“Deep learning-assisted detection of psychoactive water pollutants using behavioral profiling of zebrafish embryos” Journal of Hazardous Materials 2024, 480:136358.(IF:12.2,中科院一区top期刊)
Guoqing Hou, Weihua Hu, Yazhou Sang, Xiaocai Gan, Hui Xu, Qiongying Hu, Xuan Cao曹轩* “Corynoxine Triggers Cell Death Via Activating PP2A and Regulating AKT-mTOR /GSK3β Axes in NSCLC” Biochem Pharmacol 2024, 222:116110(IF:5.3,中科院二区,药理学国际知名期刊)
2023年度:
Hui Xu#, Ming Tan#, Guo-Qing Hou, Ya-Zhou Sang, Li Lin, Xiao-Cai Gan, Xuan Cao曹轩*, An-Dong Liu* “Blockade of DDR1/PYK2/ERK signaling suggesting SH2 superbinder as a novel autophagy inhibitor for pancreatic cancer” Cell Death Disease 2023, 14(12): 811 (IF: 9,中科院一区top期刊)
Feng Liu# , Qian Zhou#, Hai-Feng Jiang#, Ting-Ting Zhang, Cheng Miao, Xiao-Hong Xu, Jia-Xing Wu, Song-Lin Yin, Shi-Jie Xu, Jing-Yi Peng, Pan-Pan Gao, Xuan Cao曹轩*, Feng Pan*, Ximiao He*, Xiao Qian Chen* “Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity” J Exp Clin Cancer Res 2023 42(1):118 (IF: 11.3,中科院一区top期刊)
2015-2022年:
Meng Wang#, An-Dong Liu#, Qian Niu, Shawn Shun-Cheng Li, Wan-Li Ma*,Xuan Cao曹轩*, Hong Ye*“Blockade of Phosphotyrosine Pathways Suggesting SH2 Superbinder as a Novel Therapy for Pulmonary Fibrosis” THERANOSTICS 2022 12(10):4513-4535(IF:12.4,中科院一区top期刊)
Xi Zhang#, Hui Xu#, Xiaoyang Bi, Guoqing Hou, Andong Liu,Youyun Zhao,Guoping Wang*,Xuan Cao曹轩*“Src acts as thetargetof matrineto inhibitthe proliferation of cancercells by regulatingphosphorylation signaling pathways”CELL DEATH DIS 2021 12:931 (IF:9,中科院一区top期刊)
Lin Xu, Xinge Zhang, Yue Xin, Jie Ma, Chenyan Yang, Xi Zhang, Guoqing Hou, X Charlie Dong, Zhaoli Sun, Xiwen Xiong*,Xuan Cao曹轩*“Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway” CELL DEATH DIS 2021 12:710 (IF: 9,中科院一区top期刊)
An-Dong Liu#, Jie Zhou#, Xiao-Yang Bi, Guo-Qing Hou, Shawn Shun-Cheng Li, Qing Chen, Hui Xu,Xuan Cao曹轩*“Aptamer-SH2 Superbinder based targeted therapy for Pancreatic ductal adenocarcinoma”CLIN TRANSL MED 2021 11:e337(IF:10.6,中科院一区期刊)
Jie Deng,Chunmei Wen,Xiangyu Ding,Xi Zhang,Guoqing Hou,Andong Liu,Hui Xu,Xuan Cao曹轩*,Yongheng Bai*,“LKB1-MARK2signalling mediates lipopolysaccharide-induced production of cytokines in mouse macrophages”J Cell Mol Med 2020 24(19):11307-11317 (IF:5.3,中科院二区top期刊)
Xi Zhang, Guoqing Hou, Andong Liu, Hui Xu, Yang Guan,Yaosong Wu, Jie Deng,Xuan Cao曹轩*,“Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways.”
CELL DEATH DIS2019 10(10):770 (IF: 9,中科院一区top期刊)
Jie Deng#, An-Dong Liu#,Guo-Qing Hou,Xi Zhang,Kun Ren,Xuan-Zuo Chen, ShawnS.C.Li,Yao-SongWu,Xuan Cao曹轩*, "N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling. "J EXP CLIN CANC RES2019 38:2 (IF: 11.3,中科院一区top期刊)
Wenjiao Li, Ning Li, Shiyu Dai, Guoqing Hou, Kanglin Guo, Xuanzuo Chen, Changhua Yi, Weiyong Liu, Fei Deng, Yaosong Wu*,Xuan Cao曹轩*,“Zika virus circumvents host innate immunity by targeting the adaptor protein MAVS and MITA.”FASEB Journal 2019 33(9):9929-9944(IF:4.8,中科院二区top期刊)
Ai-Qing Ke#, An-Dong Liu#, Ya-Nan Gao, Dan-Ni Luo, Zhao-Feng Li, Yue-Qi Yu, Jia-Ying Liu, Hui Xu*,Xuan Cao曹轩*, "Development of novel affinity reagents for detecting protein tyrosine phosphorylation based on superbinder SH2 domain in tumor cells. "ANAL CHIM ACTA2018 1032:138-146 (IF: 6.2,中科院小类一区top期刊)
An-dong Liu#, Hui Xu#, Ya-nan Gao,Dan-ni Luo,Zhao-fengLi,Courtney Voss, Shawn S.C. Li,Xuan Cao曹轩*, "(Arg)9-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling. "J EXP CLIN CANC RES 2018 37(1):138 (IF: 11.3,中科院一区top期刊)
Cao X曹轩,Kaneko T, Li JS, Liu AD, Voss C, Li SS.,“A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.”NAT COMMUN 2015 6:7721(IF: 16.6,中科院一区top期刊)
2015年之前:
Cao X曹轩,Voss C, Zhao B, Kaneko T, Li SS.,“Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation.”P NATL ACAD SCI USA2012 109(5):1455-60. (IF: 11.1,中科院一区top期刊)
Cao X曹轩,Wang YF, Zhang CF, Gao WJ., “Visual DNA microarrays for simultaneous detection of Ureaplasma urealyticum and Chlamydia trachomatis coupled with multiplex asymmetrical PCR.”, Biosens Bioelectron.2006 22(3):393-8. (IF:12.6,中科院一区top期刊)
发明专利:
中国发明专利:
快速检测沙眼衣原体的荧光定量PCR试剂盒(第一发明人)
快速检测细小脲原体的荧光定量PCR试剂盒(第一发明人)
同步检测沙眼衣原体和细小脲原体的荧光定量PCR试剂盒(第二发明人)
一种突变的IRS-1的PTB结构域蛋白及其编码序列和应用(第一发明人)
国际发明专利:
SH2 domain variants (PCT国际发明专利,中美加,第三发明人)
专业硕士招生专业:
1.化学工程专业
2.生物与医药专业
3.护理学
联系方式:
地址:台州学院医学院302室
Email:caoxuanwhu@126.com