师资队伍

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医学基础部

陈光(女)


姓名:陈光 职称:教授

主要学习与工作经历:

       199409-199707月:黑龙江中医药大学临床医学

       200209-200507月:佳木斯大学基础医学院医学免疫学硕士

       200509-200807月:中国医科大学基础医学院医学免疫学博士

       201010-201211月:加拿大McMaster UniversityDivision of  Nephrology博士后

       199707-200808月:佳木斯大学基础医学院讲师

       200809-201608月:佳木斯大学基础医学院副教授

       201609-201812月:佳木斯大学基础医学院教授

       201901-至今  台州学院医学院教授

主要学术成果与荣誉:

1. 陈光,李丽,罗兰,候杰。疟疾/弓形虫感染过程中Treg对免疫应答和免疫病理效应机制的调控作用研究。黑龙江省人民政府,科学技术奖三等奖,2015.12

2. 陈光,刘蕾,李丽,罗兰,候杰。疟疾/弓形虫感染过程中CD4+CD25+Foxp3+ T细胞对免疫应答和免疫病理效应机制的调控作用。黑龙江省教育厅,黑龙江高校科技技术一等奖,2015.02-03

主要研究方向:抗感染免疫;炎症性皮肤病的免疫学发病机制

主要研究/教学论文(第一作者或通讯作者):

1. Chen JG, Du YT, Guan CH, Fan HY, Liu YA, Wang T, Li X, Chen G*.Extracellular Vesicles derived from Plasmodium-infected Hosts as Stimuli of ''Trained'' Innate Immunity.Curr Med Chem. 2023 Feb 7.

2. Chen G, Li F, Du J.Change of gut microbiome structure in preterm infants with hypoxic ischemic encephalopathy induced by apnea.Pediatr Neonatol. 2023 Jan 25:S1875-9572(23)00022-0.

3. Chen G, Liu SC, Fan XY, Jin YL, Li X, Du YT. Plasmodium manipulates the expression of host long non-coding RNA during red blood cell intracellular infection.Parasit Vectors. 2022 May 28;15(1):182.

4. Qiu-bo Wang, Yun-ting Du, Fei Liu, Xiao-dan Sun, Xun Sun, Guang Chen*, Wei Pang and Ya-Ming Cao. Adaptive immune responses mediated age-related Plasmodium yoelii 17XL and 17XNL infections in 4 and 8-week-old BALB/c mice. BMC Immunology,2021 Jan 11;22(1):6.

5. Chen G, Chen ZM, Fan XY, Jin YL, Li X, Wu SR, Ge WW, Lv CH, Wang YK, Chen JG.Gut-Brain-Skin Axis in Psoriasis: A Review. Dermatol Ther (Heidelb). 2021 Feb;11(1):25-38.

6. Chen G, Fan XY, Zheng XP, Jin YL, Liu Y, Liu SC. Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice. Stem Cell Res Ther. 2020 Sep 16;11(1):401.

7. Xiao-Peng Zheng, Qing Nie, Jing Feng, Xiao-Yan Fan,Yue-Lei Jin, Guang Chen*, Ji-Wei Du. Kidney-targeted Baicalin-Lysozyme Conjugate Ameliorates Renal Fibrosis in Rats With Diabetic Nephropathy Induced by Streptozotocin. BMC Nephrol . 2020 May 12;21(1):174.

8. Chen G, Du JW, Nie Q, Du YT, Liu SC, Liu DH, Zhang HM, Wang FF. Plasmodium yoelii 17XL infection modified maturation and function of dendritic cells by skewing Tregs and amplificating Th17. BMC Infect Dis. 2020;20(1):266.

9. Qin X, Liu J, Du Y, Li Y, Zheng L, Chen G*, Cao Y. Different doses of vitamin C supplementation enhances the Th1 immune response to early Plasmodium yoelii 17XL infection in BALB/c mice.. Int Immunopharmacol. 2019 Mar 7;70:387-395.

10. Guang Chen, Yun-Ting Du , Jian-Hua Liu , Ying Li , Li Zheng , Xiao-Song Qin , Ya-Ming Cao. Modulation of Anti-Malaria Immunity by Vitamin A in C57BL/6J Mice Infected With Heterogenic Plasmodium. Int Immunopharmacol. 2019 Nov;76:105882.

11. Bi S, Nie Q, Wang WQ, Zhu YL, Ma XM, Wang CM, Zhang BC, Li HY, Zhang Q, Chen G*. Human Umbilical Cord Mesenchymal Stem Cells Therapy for Insulin Resistance: A Novel Strategyin Clinical Implication.CurrStemCell Res Ther. 2018;13(8):658-664.

12. Chen G, Wang T, Uttarwar L, vanKrieken R, Li R, Chen X, Gao B, Ghayur A, Margetts P, Krepinsky JC. SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells.J Mol Cell Biol. 2014 Oct 26. pii: mju041.

13. Chen G, Chen X, Sukumar A, Gao B, Curley J, Schnaper HW, Ingram AJ, Krepinsky JC.TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells.J Cell Sci. 2013 Aug 15;126(Pt 16):3697-712.

14. Guan TH, Chen GCo-first author, Gao B, Janssen MR, Uttarwar L, Ingram AJ, Krepinsky JC.Caveolin-1 deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy.Diabetologia. 2013 Sep;56(9):2068-77.

发明专利:

主持的科研项目:

1. 济南凯晨生物科技有限公司,技术研发项目,痤疮治疗性抗体的制备和应用,2022-052.25-1280万,在研,主持

2. 台州学院,杰出青年项目,Z2020080,外泌体源LncRNA调控疟疾感染宿主Th应答特征谱的分子机制,2020-012022-1210万元,在研,主持

3. 黑龙江省自然科学基金委员会,重点项目,ZD2017020UC-MSCs调控db/db小鼠骨骼肌胰岛素抵抗的分子机制研究,2017-102020-1020万元,已结题,主持

4. 吉林拓华生物科技有限公司,技术研发项目,UC-MSCs调控db-/db-小鼠骨骼肌胰岛素抵抗的分子机制,2016-092019-0935万,已结题,主持

5. 黑龙江省自然科学基金委员会,归国留学项目,LC2013C34DC-Treg-Th17诱导活化在疟疾感染中的作用研究,2014-012016-125万元,已结题,主持

6. 黑龙江省教育厅,海外学人项目,1254HQ017,疟疾感染过程DC-Treg-Th17交互式作用的体外实验研究,2014-012016-127万元,已结题,主持

7. 国家自然科学基金委员会,青年基金项目,81101278DC-Treg-Th17的诱导活化及其交叉修饰在疟疾感染中的作用研究,2012-012014-1222万元,已结题,主持

联系方式:13516860856

地址:浙江省台州市椒江区市府大道1139


Emailmisschenguang75@163.com